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导师介绍

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周德敏 博士 教授

科技部973首席科学家（2010）

全国生物候选药物牵头科学家（2013）

万人计划科技创新领军人才（2018年）

北京大学药学院院长（2016-2023）

天然药物及仿生药物国家重点实验室主任（2012-）

北京大学宁波海洋药物研究院院长（2020-）

担任美国Mol Pharm杂志副主编，药学权威杂志J Med Chem和Eur J Med Chem编委

    J Chin Pharm Sci【中国药学(英文版)】的执行主编

Tel: 010-82805857

E-mail: deminzhou@bjmu.edu.cn

教育经历

1985. 08 – 1990. 07     北京医科大学，大学本科

1990. 09 – 1996. 06     北京医科大学/日本筑波大学，联合培养博士，导师：张礼和院士、Kazunari Taira教授

1999. 01 – 2002. 04     美国加州大学伯克利分校化学系/Scripps研究所博士后，指导教授：Peter G. Schultz

工作经历

1996. 07 – 1999. 12     日本筑波大学应用生物化学系，助理教授

2002. 05 – 2003. 04     美国Chugai-Roche 制药公司，高级研究员

2003. 05 – 2008. 09     美国Immusol生物制药公司，创新药物研发部责任人

2008. 10 – 今              北京大学药学院，教授、副院长、院长

国家蛋白质重大研究计划（973）项目首席科学家

天然药物及仿生药物国家重点实验室主任

国家创新药物专项生物候选药牵头科学家

研究经历

2008 – 今                     

食道癌耐放疗基因的发现与确证

基于基因密码子扩展的蛋白质标记新方法

以病毒进入细胞为靶的抗病毒药物研究

2002 – 2008   

基于RNA干扰的功能基因及药物靶标研究平台的研发

丙型肝炎药物筛选体系的建立和药物研发

蛋白药物靶点的克隆、表达及纯化

1990 – 2002   

建立小分子调控蛋白-蛋白相互作用进而控制信号通路的新方法  

核酶定点切割RNA的机理研究

靶向HCV的蛋白酶抑制剂RNA配体体外筛选    

天然物apophine类生物碱的化学全合成

课题组在研项目

  1. 科技部重点研发项目：基因密码子扩展技术及功能蛋白定向改造（2025-2029）

  2. 国家自然科学基金重点项目：基于流感病毒结构和功能仿生基础的生物技术药物研究（No. 82130100, 2022-2026）

  3. 国家自然科学基金创新研究群体：基于内源性大分子精准修饰的生物药物创新（No.81821004, 2019-2023）

  4. 国家科技重大专项：基于蛋白质定点修饰关键技术的生物药物创新及升级换代（No. 2017ZX09309009, 2018-2020）

  5. 国家自然科学基金重大研究计划：基于病毒包膜蛋白时空动态修饰的病毒-细胞融合研究及化学干预、靶点发现和转化（No. 91753202, 2018-2021）

  6. 国家重点研发计划“蛋白质机器与生命过程调控”专项：“信号转导过程中蛋白质机器的活细胞标记与在体调控”项目之子课题3：“活细胞及活体内蛋白质功能的原位研究与靶向干预”（No.2016YFA0501500, 2017-2021）

  7. 国家自然科学基金重点项目：基于膜蛋白定点修饰的重组病毒载体结构基础、输送靶向性及免疫原不良反应关系研究（No. 81530090, 2016-2020）

  8. 国家自然科学基金面上项目：新型五环三萜-环糊精多价物的合成、抗流感进入构效关系及分子机制研究（No. 81573269，2016-2019）

  9. 国家自然科学基金面上项目：五环三萜化合物调控多种RNA病毒感染的共性分子机制和结构基础研究（No. 21572015，2016-2019）

  10. 国家自然科学基金面上项目：埃博拉病毒单病毒颗粒荧光示踪及病毒与宿主细胞互作过程的研究（No.81572004, 2016-2019）

  11. 国家自然科学基金国际合作与交流项目：基于三萜类化合物调控流感病毒与宿主细胞识别的新型抗病毒药物研究（No. 81361168002, 2014-2017）

  12. 国家自然科学基金面上项目：以“病毒进入细胞”为靶的五环三萜抗HCV病毒药物研究（No. 81373271, 2014-2017）

  13. 科技部创新药物重大专项：新型生长激素候选生物药物研究（No. 2013ZX09103003, 2013-2015）

  14. 国家自然科学基金委重大研究计划：非可控性炎症口腔扁平苔藓恶性转化的分子机制研究（No. 91029711, 2011-2013）

  15. 国家自然科学基金委重点项目：结构修饰的 siRNA 合成和 RNA 干扰技术在药物靶标寻找中的应用（No. 20932001, 2010-2012）

  16. 科技部“973”重大研究计划：基于基因密码子扩展的蛋白质标记新方法（No. 2010CB912300，2010-2014，首席科学家）

荣誉奖励

  1. 中国2023年度重要医学进展（生物医学工程与信息领域）（2024.04）

  2. 国务院政府特殊津贴专家（2019.03）

  3. 2018年第十九届吴阶平-保罗·杨森医学药学奖（2018.11）

  4. 2018年美洲华人药学会 American-Sina Pharmaceutic Life Time Achievement Award 奖（2018.11）

  5. 2017年药明康德生命化学研究奖杰出成就奖（2017.12）

  6. 国家“万人计划”科技创新领军人才 （2017）

  7. 2016年国际疫苗学会年度突破奖（Paper of the Year）

  8. 2016年中国医学十大进展（2016）

  9. 教育部长江学者教授（2013-2018）

  10. 国家“973”项目首席科学家（2010-2014）

  11. 国家自然科学二等奖（2004）

  12. 中国教育部科技进步一等奖（1998）

  13. 全国首届优秀博士毕业论文（1999）

 

   代表性论文 

   

  1. Wu Y, Shan X, Zhang Y, Shi W, Zhu X, Yu M, Xie S, Guo L, Chen Z, Zhang C,* Zhou D,* Cai Z.* Bioorthogonal surface-edited exosomes for targeted multimodal imaging and synergic chemophototherapy of oral cancer. Chem. Eng. J., 2024, 497, 154653

  2. Zhang Y, Chen Z, Wang X, Yan R, Bao H, Chu X, Guo L, Wang X, Li Y, Mu Y, He Q, Zhang L, Zhang C,* Zhou D,* Ji D.* Site-specific tethering nanobodies on recombinant adeno-associated virus vectors for retargeted gene therapy. Acta Biomater., 2024, 187, 304-315

  3. Ji D,*,# Zhang Y,# Sun J, Zhang B, Ma W, Cheng B, Wang X, Li Y, Mu Y, Xu X, Wang Q, Zhang C, Xiao S, Zhang L, Zhou D.* An engineered influenza virus to deliver antigens for lung cancer vaccination. Nat. Biotech., 2024, 42, 518-828.

  4. Zhu XX,# Yi YL,# Fan ZB,# Liu RW, Chu XD, Wang MY, Zhang JY, Tretyakova, E, Zhang YM, Zhang LH, Zhou DM, Xiao SL.* Novel mono- and multivalent N-acetylneuraminic acid glycoclusters as potential broad-spectrum entry inhibitors for influenza and coronavirus infection. Eur. J. Med. Chem.,  2023, 260, 115723

  5. Zhang B*, Sun J, Yuan Y, Ji D, Sun Y, Liu Y, Li S, Zhu X, Wu X, Hu J, Xie Q, Wu L, Liu L, Cheng B, Zhang Y, Jiang L, Zhao L, Yu F, Song W, Wang M, Xu Y, Ma S, Fei Y, Zhang L, Zhou D*, Zhang X*. Proximity-enabled covalent binding of IL-2 to IL-2Rα selectively activates regulatory T cells and suppresses autoimmunity. Signal Transduc. Target. Ther., 2023, 8(1), 28

  6. Chen B, Chu X, Liu R, Ma X, Wang M, Zhang J, Jiao P, Gao Q, Ma W, Zhang Y, Zhao C,* Zhou D, Xiao S.* Synthesis of novel pentacyclic triterpenoid derivatives that induce apoptosis in cancer cells through a ROS-dependent, mitochondrial-mediated pathway. Mol. Pharm., 2023, 20, 701-710

  7. 周德敏,* 李海伟, 肖苏龙. 中药抗病毒的物质基础: 从五环三萜说开来. 北京大学学报（医学版）, 2022, 54(5), 832-836

  8. Li H, Wang S, Ma W, Cheng B, Yi Y, Ma X, Xiao S,* Zhang L, Zhou D.* Discovery of pentacyclic triterpenoid PROTACs as a class of effective hemagglutinin protein degraders. J. Med. Chem., 2022, 65(10), 7154-7169.

     

     

  9. Liang S,# Ma X,# Li M, Yi Y, Gao Q, Zhang Y, Zhang L, Zhou D, Xiao S.* Novel β-cyclodextrin-based heptavalent glycyrrhetinic acid conjugates: Synthesis, characterization and anti-influenza activity. Front. Chem., 2022, 10, 836955

  10. Li G,# Ma W,# Mo J, Cheng B, Shoda S, Zhou D,* Ye X.* Influenza virus precision diagnosis and continuous purification enabled by neuraminidase-resistant glycopolymer-coated microbeads. ACS Appl. Mater. Interfaces, 2021, 13(39), 46260-46269.

     

  11. Su X,# Ma W,# Feng D, Cheng B, Wang Q, Guo Z, Zhou D,* Tang X.* Efficient inhibition of SARS-CoV-2 using chimeric antisense oligonucleotides through RNase L activation. Angew. Chem. Int. Ed., 2021, 60, 21662–21667

  12. Chen Y,# Wang X,# Ma X, Liang S, Gao Q, Tretyakova E, Zhang Y, Zhou D, Xiao S.* Facial synthesis and bioevaluation of well-defined OEGylated betulinic acid-cyclodextrin conjugates for inhibition of influenza infection. Molecules, 2022, 27(4), 1163

     

     

  13. Yi Y, Ma X, Liu R, Chu X, Li H, Zhang J, Gao Q, Zhang Y, Zhang L, Zhou D, Xiao S.* An attempt to synthesize the two monomers of CDTOH: unexpected NMR and X-ray diffraction crystal analysis.Tetrahedron Lett., 2022, 91, 153638.

  14. Zhang B,# Wang Y,# Sun J,# Ji D,# Yuan Y,# Li S, Sun Y, Hou Y, Li P, Zhao L, Yu F, Ma W, Cheng B, Wu L, Hu J, Wang M, Chen H, Fei Y, Song W, Li X, Li H, Zhang L, Tsokos G, Zhou D,* Zhang X.*Site-specific PEGylation of interleukin-2 enhances immunosuppression via the sustained activation of regulatory T cells. Nat. Biomed. Eng., 2021, 5, 1288-1305.

     

     

  15. Zhang B,# Wang Y,# Yuan Y,# Sun J, Liu L, Huang D, Hu J, Wang M, Li S, Song W, Chen H, Zhou D,* Zhang X.*In vitro elimination of autoreactive B cells from rheumatoid arthritis patients by universal chimeric antigen receptor T cells. Ann. Rheum. Dis., 2021, 80 (2), 176-184

  16. Zhang B,# Wang Y,# Huang S,# Sun J, Wang M, Ma W, You Y, Wu L, Hu J, Song W, Liu X, Li S, Chen H, Zhang G, Zhang L, Zhou D,* Li L,* Zhang X.* Photoswitchable CAR-T cell function in vitro and in vivo via a cleavable mediator. Cell Chem. Biol., 2021, 28 (1), 60-69

  17. Li H, Sun J, Xiao S,* Zhang L, Zhou D.* Triterpenoid-mediated inhibition of virus-host interaction: Is now the time for discovering viral entry/release inhibitors from nature? J. Med. Chem., 2020, 63 (24), 15371-15388

  18. Li M, Yuan L,* Chen Y, Ma W, Ran F, Zhang L, Zhou D, Xiao S.* Rhodamine B-based fluorescent probes for molecular mechanism study of the anti-influenza activity of pentacyclic triterpenes. Eur. J. Med. Chem., 2020, 205, 112664.

  19. Xiao S,* Zhou D, Zhang L, Sinaÿ P, Zhang Y.* Preparation of unsymmetrically 2A,3B,6C(F)-trihydroxy-per-O-methylated α-cyclodextrin and NMR analysis. Tetrahedron Lett., 2020, 61(33), 152224.

  20. Chen Y#, Wang X#, Zhu Y#, Si L, Zhang B, Zhang Y, Zhang L, Zhou D, Xiao S.* Synthesis of a hexavalent betulinic acid derivative as a hemagglutinin-targeted influenza virus entry inhibitor. Mol. Pharm., 2020, 17(7), 2546-2554

  21. Wang H, Xu R, Liang S, Ran F, Zhang L, Zhang Y, Zhou D, Xiao S.* Selective and facile deacetylation of pentacyclic triterpenoid under methanolic ammonia condition and unambiguous NMR analysis. Chin. Chem. Lett., 2020, 31(2), 333-336

  22. Wang Y,# Li S,# Tian Z, Sun J, Liang S, Zhang B, Bai L, Zhang Y, Zhou X, Xiao S, Zhang Q, Zhang L, Zhang C,* Zhou D.* Generation of a caged lentiviral vector through an unnatural amino acid for photo-switchable transduction. Nucleic Acids Res., 2019,47(19), e114.

  23. Liang S,# Li M,# Yu X, Jin H, Zhang Y, Zhang L, Zhou D, Xiao S.* Synthesis and structure-activity relationship studies of water-soluble β-cyclodextrin-glycyrrhetinic acid conjugates as potential anti-influenza virus agents. Eur. J. Med. Chem., 2019, 166, 328-338.

  24. Li H,# Li M,# Xu R,# Wang S, Zhang Y, Zhang L, Zhou D,* Xiao S.* Synthesis, structure activity relationship and in vitro anti-influenza virus activity of novel polyphenol-pentacyclic triterpene conjugates. Eur. J. Med. Chem., 2019, 163, 560-568.

  25. Jiao P, Wang S, Liang S, Li M, Gao Q, Ji D, Chen Y, Li H, Ran F, Zhang Y, Zhang L, Zhou D,* Xiao S.* Facile preparation and characterization of novel oleanane-type triterpene functionalized β-cyclodextrin conjugates. Chin. Chem. Lett., 2019, 30(3), 690-693.

  26. Si L, Meng K, Tian Z, Zhang Z, Soloveva V, Li H, Fu G, Xia Q, Xiao S, Zhang L, Cunningham J. M, Zhou D.* Triterpenoids manipulate a broad range of virus-host fusion via wrapping the HR2 domain prevalentin viral envelopes. Sci. Adv., 2018, 11(4), eaau8408.

  27. Zhang C,* Zhou D.* Chemical modification strategies of viral vectors for gene therapy. Sci. Sin. Chim., 2018, 48 (11), 1365-1375.

  28. Li M, Li H, Liang S, Tian Z, Zhou D, Xiao S.* Recent progresses of novel anti-influenza entry inhibitors. Sci. Sin. Chim., 2018, 48(11) , 589-599.

  29. Zhang C*, Zhou X, Yao T, Tian Z, Zhou D*. Precision fluorescent labeling of an adeno-associated virus vector to monitor the viral infection pathway. Biotechnol. J., 2018, 13(4), e1700374.

  30. Zhu X, Xiao S, Zhou D, Sollogoub M, Zhang Y*. Design, synthesis and biological evaluation of water-soluble per-O-methylated cyclodextrin-C60 conjugates as anti-influenza virus agents. Eur. J. Med. Chem., 2018, 146, 194-205.

  31. Xiao S,* Tian Z, Wang Y, Si L, Zhang L, Zhou D.* Recent progress in the antiviral activity and mechanism study of pentacyclic triterpenoids and their derivatives. Med. Res. Rev. 2018, 38(3), 951-976.

  32. Wang Y,# Wu X,# Du M, Chen X, Ning X, Chen H, Wang S, Liu J, Liu Z, Li R, Fu G, Wang C, McNutt MA, Zhou D,* Yin Y.* Eg5 inhibitor YL001 induces mitotic arrest and inhibits tumor proliferation. Oncotarget., 2017, 8(26), 42510-42524

  33. Meng L, Wang Q, Tang T, Xiao S, Zhang L, Zhou D, Yu F.* Design, synthesis and biological evaluation of pentacyclic triterpene dimers as HCV entry inhibitors. Chin. J. Chem., 2017, 35(8), 1322-1328

  34. Wang W, Zhao Z, Zhang Z, Zhang C, Xiao S, Ye X, Zhang L, Xia Q,* Zhou D.* Redirecting Killer T Cells through Incorporation of Azido Sugars for Tethering Ligands. Chembiochem, 2017, 18(21), 2082-2086.

  35. Zhang Z, Xu H, Si L, Chen Y, Zhang B, Wang Y, Wu Y, Zhou X, Zhang L, Zhou D.* Construction of an inducible stable cell line for efficient incorporation of unnatural amino acids in mammalian cells. Biochem. Biophys. Res. Commun., 2017, 489(4), 490-496.

  36. Zhang C,#,* Lu J,# Su H, Yang J, Zhou D.* Fatty acid synthase cooperates with protrudin to facilitate membrane outgrowth of cellular protrusions. Sci. Rep., 2017, 7, 46569

  37. Yao T,# Zhou X,# Zhang C,* Yu X, Tian Z, Zhang L, Zhou D.* Site-specific PEGylated adeno-associated viruses with increased serum stability and reduced immunogenicity. Molecules 2017, 22(7), 1155

  38. Shi Y,# Si L,# Han X,# Fan Z, Wang S, Tian Z, Li M, Sun J, Jin H, Zhang Y, Zhou D, Xiao S.* Synthesis of novel pentacyclic triterpene-Neu5Ac2en derivatives and investigation of their in vitro anti-influenza entry activity. MedChemComm. 2017, 8, 1531-1541

  39. Han X,# Si L,# Shi Y, Fan Z, Wang S, Tian Z, Li M, Sun J, Jiao P, Ran F, Zhang Y, Zhou D, Xiao S.* Synthesis and in vitro anti-influenza virus evaluation of novel sialic acid (C-5 and C-9)-pentacyclic triterpene derivatives. Molecules 2017, 22(7), 1018

  40. Tian Z,# Si L,# Meng K, Zhou X, Zhang Y, Zhou D, Xiao S.*  Inhibition of influenza virus infection by multivalent pentacyclic triterpene-functionalized per-O-methylated cyclodextrin conjugates. Eur. J. Med. Chem. 2017,134, 133-139

  41. Tian Z, Meng K, Shi Y, Zhang N, Liu X, Jin H, Zhang Y, Zhang L, Zhou D, Xiao S.* Facile preparation of a symmetric hexavalent oleanolic acid/per-O-methylated α-cyclodextrin conjugate with two conformations in solution and unambiguous NMR analysis. Tetrahedron 2017, 73 (17), 2512-2517. （"Front Cover Article"）

  42. Wu S, Yang L, Sun W, Si L, Xiao S, Wang Q, Dechoux L, Thorimbert S, Sollogoub M, Zhou D, Zhang Y.* Design, synthesis and biological evaluation of gentiopicroside derivatives as potential antiviral inhibitors. Eur. J. Med. Chem.; 2017, 130, 308-319.

  43. Wu L,# Chen J,# Wu Y,# Zhang B, Cai X, Zhang Z, Wang Y, Si L, Xu H, Zheng Y, Zhang C, Liang C, Li J, Zhang L, Zhang Q, Zhou D.* Precise and combinatorial PEGylation generates a low-immunogenic and stable form of human growth hormone. J. Control Release, 2017, 249, 84-93.

  44. Si L,# Xu H,# Zhou X, Zhang Z, Tian Z, Zhang B, Niu Z, Yao T, Wang Y, Li S, Zhang C, Fu G, Xiao S, Xia Q, Zhang L, Zhou D*. Generation of influenza A viruses as live but replication-incompetent virus vaccines. Science 2016, 354(6316), 1170-1173.

  45. Zhang C, Yao T, Zheng Y, Li Z, Zhang L, Zhou D*. Data on interaction between adeno-associated virus and U87 cell via cRGD chemical modification. Data Brief. 2016, 7, 77-80.

  46. Wu Y,# Zhu H,# Zhang B, Liu F, Chen J, Wang Y, Wang Y, Zhang Z, Wu L, Si L, Xu H, Yao T, Xiao S, Xia Q, Zhang L, Yang Z,* Zhou D.* Synthesis of site-specific radiolabeled antibodies for radioimmunotherapy via genetic code expansion. Bioconjug. Chem.; 2016, 27(10), 2460-2468

  47. Xiao S,* Wang Q, Si L, Zhou X, Zhang Y, Zhang L, Zhou D.* Synthesis and biological evaluation of novel pentacyclic triterpene α-cyclodextrin conjugates as HCV entry inhibitors. Eur. J. Med. Chem.; 2016, 124, 1-9

  48. Han X, Shi Y, Si L, Fan Z, Wang H, Xu R, Jiao P, Meng K, Tian Z, Zhou X, Jin H, Wu X, Chen H, Zhang Y, Zhang L, Xiao S,* Zhou D.* Design, synthesis and biological activity evaluation of novel conjugated sialic acid and pentacyclic triterpene derivatives as anti-influenza entry inhibitors. MedChemComm.; 2016, 7, 1932-1945 ("HOT" Article)

  49. Yu F,* Wang Q, Wang H, Si L, Liu J, Han X, Xiao S, Zhang L, Zhou D.* Synthesis and biological evaluation of echinocystic acid derivatives as HCV entry inhibitors. Chin. Chem. Lett.; 2016, 27, 711-713

  50. Xu H, Wang Y, Lu J, Zhang B, Zhang Z, Si L, Wu L, Yao T, Zhang C, Xiao S, Zhang L, Xia Q,* Zhou D.* Re-exploration of the codon context effect on amber codon-guided incorporation of non-canonical amino acids in E. coli by the blue-white screening assay. Chembiochem.; 2016, 17, 1-8.

  51. Han Wang, Renyang Xu, Yongying Shi, Longlong Si, Pingxuan Jiao, Zibo Fan, Xu Han, Xingyu Wu, Xiaoshu Zhou, Fei Yu, Yongmin Zhang, Lihe Zhang, Demin Zhou*, Sulong Xiao*. Design, synthesis and biological evaluation of novel L-ascorbic acid-conjugated pentacyclic triterpene derivatives as potential influenza virus entry inhibitors. Eur. J. Med. Chem.; 2016, 110, 376-388

  52. Fei Yu,* Yongxiang Zheng, Yiyun Peng, Demin Zhou, Sulong Xiao.* Design and synthesis of ring A and/or C expansion and opening oleanolic acid derivatives. Chin. J. Org. Chem.; 2016, 36, 512-519

  53. Bo Zhang, Qi Yang, Jingxian Chen, Ling Wu, Tianzhuo Yao, Yiming Wu, Huan Xu, Lihe Zhang, Qing Xia*, Demin Zhou*. CRISPRi-manipulation of genetic code expansion via RF1 for reassignment of amber codon in bacteria. Sci. Rep.; 2016, 6, 20000

  54. Chuanling Zhang, Tianzhuo Yao, Yongxiang Zheng, Zhongjun Li, Lihe Zhang, Demin Zhou*. Development of next generation adeno-associated viral vectors capable of selective tropism and efficient gene delivery. Biomaterials. 2016, 80: 134-145.

  55. Sulong Xiao,* Longlong Si, Zhenyu Tian, Pingxuan Jiao, Zibo Fan, Kun Meng, Xiaoshu Zhou, Han Wang, Renyang Xu, Xu Han, Ge Fu, Yongmin Zhang, Lihe Zhang, Demin Zhou*. Pentacyclic triterpenes grafted on CD cores to interfere with influenza virus entry: A dramatic multivalent effect. Biomaterials. 2016, 78, 74-85.

  56. Siwen Niu, Longlong Si, Dong Liu, Andrew Zhou, Ziwei Zhang, Zongze Shao, Shaomeng Wang, Lihe Zhang, Demin Zhou,* Wenhan Lin.* Spiromastilactones: a new class of influenza virus inhibitors from deep-sea fungus. Eur. J. Med. Chem. 2016, 102, 594-599.

  57. Wang Q, Qiao X, Qian Y, Li ZW, Tzeng YM, Zhou DM*, Guo DA, Ye M*. Intestinal Absorption of Ergostane and Lanostane Triterpenoids from Antrodia cinnamomea Using Caco-2 Cell Monolayer Model. Nat. Prod. Bioprospect. 2015, 5(5): 237-246

  58. Shuai Ji, Ru Li, Qi Wang,Wen-juan Miao,Zi-wei Li, Long-long Si, Xue Qiao, Si-wang Yu, De-min Zhou,* Min Ye.* Anti-H1N1 virus, cytotoxic and Nrf2 activation activities of chemical constituents from Scutellaria baicalensis. Journal of Ethnopharmacology. 2015, 176, 475-484

  59. Wen Shi, Jing Yang (Co-first author), Siyuan Li, Xiaofeng Shan, Xiaosong Liu, Hong Hua, Chuanke Zhao, Zhendong Feng, Zhigang Cai, Lihe Zhang, Demin Zhou.* Potential involvement of miR-375 in the premalignant progression of oral squamous cell carcinoma mediated via transcription factor KLF5. Oncotarget. 2015, 6(37): 40172-40185.

  60. 肖苏龙, 王晗, 王琪, 韩旭, 徐仁洋, 孟坤, 田振宇, 张礼和, 周德敏.* 基于五环三萜先导结构的抗病毒抑制剂研究进展. 中国科学(化学). 2015, 45(9): 865-883

  61. Han Wang, Fei Yu, Yiyun Peng, Qi Wang, Xu Han, Renyang Xu, Xiaoshu Zhou, Chuanxing Wan, Zibo Fan, Pingxuan Jiao, Yongmin Zhang, Lihe Zhang, Demin Zhou, Sulong Xiao.* Synthesis and biological evaluation of ring A and/or C expansion and opening echinocystic acid derivatives for anti-HCV entry inhibitors. European Journal of Medicinal Chemistry. 2015, 102: 594-599

  62. Bo Zhang, Huan Xu, Jingxian Chen, Yongxiang Zheng, Yiming Wu, Longlong Si, Ling Wu, Chuanling Zhang, Gang Xia, Lihe Zhang, and Demin Zhou*. Development of next generation of therapeutic IFN-alpha2b via genetic code expansion. Acta Biomaterialia. 2015, 9: 100-111

  63. Zheng, Yongxiang; Yu, Fei; Wu, Yiming; Si, Longlong; Xu, Huan; Zhang, Chuanling; Xia, Qing; Xiao, Sulong; Wang, Qi; He, Qiuchen; Chen, Peng; Wang, Jiangyun; Zhang, Li He;* Taira, Kazunari; Zhou, Demin.* Broaden the versatility of lentiviral vector as a tool in nucleic acid research via genetic code expansion. Nucleic Acids Res., 2015, 43(11):e73

  64. Xueqing Chen, Longlong Si (Co-first author), Dong Liu, Peter Proksch, Lihe Zhang, Demin Zhou,* Wenhan Lin.* Neoechinulin B and its analogues as potential entry inhibitors of influenza viruses, targeting viral hemagglutinin. Eur. J. Med. Chem., 2015, 93: 182-195.

  65. Maorong Yu, Longlong Si, Yufei Wang, Yiming Wu, Fei Yu, Pingxuan Jiao, Yongying Shi, Han Wang, Sulong Xiao, Ge Fu, Ke Tian, Yitao Wang, Zhihong Guo, Xinshan Ye, Lihe Zhang and Demin Zhou.* Discovery of Pentacyclic Triterpenoids as Potential Entry Inhibitors of Influenza Viruses. J. Med. Chem. 2014, 57(23): 10058-10071

  66. Yingbo Li, Jinxi Wang, Xing Gao, Weihua Han, Yongxiang Zheng, Huan Xu, Chuanling Zhang, Qiuchen He, Lihe Zhang, Zhongxin Li* and Demin Zhou*. c-Met targeting enhances the effect of irradiation and chemical agents against malignant colon cells harboring a KRAS mutation. PlosOne. 2014. 9(11): e113186

  67. Wei Xiong, Jing Zhao, Hongliang Yu, Xiaoying Li, Shaoqian Sun, Yi Li, Qing Xia, Chuanling Zhang, Qiucheng He, Xianshu Gao, Lihe Zhang, Demin Zhou.* Elevated expression of AKR1C3 increases resistance of cancer cells to ionizing radiation via modulation of oxidative stress. PlosOne. 2014. 9(11): e111191

  68. Zhendong Feng, Wen Shi, Zhigang Cai, Hong Hua, Demin Zhou*. Detection of microRNA expressions in tissues and exfoliative cells reveals the potential role of miR-203 in oral lichen planus. Journal of Chinese Pharmaceutical Sciences. 2014, 23 (5), 279-286.

  69. Zhang, Jinming; Li, Yingbo; Fang, Xiefan; Zhou, Demin; Wang, Yitao; Chen, Meiwan.* TPGS-g-PLGA/Pluronic F68 mixed micelles for tanshinone IIA delivery in cancer therapy. International Journal of Pharmaceutics (Amsterdam, Netherlands). 2014, 476(1-2), 185-198.

  70. Junfeng Wang, Yingbo Li, Nikul G. Patel, Ge Zhang, Demin Zhou, Yi Pang*. A single molecular probe for multi-analyte (Cr3+, Al3+ and Fe3+) detection in aqueous medium and its biological application. Chemical Communications. 2014, 50(82), 12258-12261.

  71. Wang, Qian; Sun, Tingting; Xu, Jianfeng; Shen, Zhouxin; Briggs, Steven P.; Zhou, Demin; Wang, Lei. Response and Adaptation of Escherichia coli to Suppression of the Amber Stop Codon. ChemBioChem. 2014, 15 (12), 1744-1749.

  72. Song, Wei; Si, Longlong; Ji, Shuai; Wang, Han; Fang, Xiao-mei; Yu, Li-yan; Li, Ren-yong; Liang, Lina; Zhou, Demin; Ye, Min. Uralsaponins M-Y, Antiviral Triterpenoid Saponins from the Roots of Glycyrrhiza uralensis. Journal of Natural Products. 2014, 77(7), 1632-1643.

  73. Wang, Junfeng; Li, Yingbo; Duah, Ernest; Paruchuri, Sailaja; Zhou, Demin; Pang, Yi. A selective NIR-emitting zinc sensor by using Schiff base binding to turn-on excited-state intramolecular proton transfer. Journal of Materials Chemistry B: Materials for Biology and Medicine. 2014, 2(14), 2008-2012.

  74. Sulong Xiao, Qi Wang, Longlong Si, Yongying Shi, Han Wang, Fei Yu, Yongmin Zhang, Yingbo Li, Yongxiang Zheng, Chuanling Zhang, Chunguang Wang, Lihe Zhang, Demin Zhou.* Synthesis and anti-HCV entry activity studies of new β-cyclodextrin-pentacyclic triterpene conjugates. ChemMedChem., 2014, 9(5): 1060-1070.

  75. Fei Yu, Yiyun Peng, Qi Wang, Yongying Shi, Longlong Si, Han Wang, Yongxiang Zheng, Emily Lee, Sulong Xiao, Maorong Yu, Yingbo Li, Chuanling Zhang, Hengli Tang, Chunguang Wang, Lihe Zhang, and Demin Zhou,* Development of bivalent oleanane-type triterpenes as potent HCV entry inhibitors. Eur. J. Med. Chem., 2014, 77: 258-268.

  76. Aigang Yang, Longlong Si, Zhenping Shi, Li Tian, Dong Liu, Demin Zhou, Peter Proksch, and Wenhan Lin. Nitrosporeusines A and B, Unprecedented Thioester-Bearing Alkaloids from the Arctic Streptomyces nitrosporeus. Org. Lett.; 2013, 15(20): 5366-5369.

  77. Fe Yu, Qi Wang, Zhen Zhang, Yiyun Peng, Yongying Shi, Yongxiang Zheng, Sulong Xiao,* Han Wang, Yongyan Qiu, Xiaoxi Huang, Chuanke Zhao, Chuanling Zhang, Dian Sun, Lihe Zhang and Demin Zhou*. Development of oleanane-type triterpene as a new class of HCV entry inhibitors. J. Med. Chem. 2013, 56(11): 4300-4319.

  78. Li YB, Wang ZQ, Yan X, Chen MW, Bao JL, Wu GS, Ge ZM, Zhou DM, Wang YT, Li RT. IC-4, a new irreversible EGFR inhibitor, exhibits prominent anti-tumor and anti-angiogenesis activities. Cancer lett., 2013, 340(1):88-96.

  79. Sulong Xiao, Ming Yang, Fei Yu, Lihe Zhang, Demin Zhou*, Pierre Sinaÿ, Yongmin Zhang.* Synthesis of four mono-functionalized α-cyclodextrin derivatives for further confirming DIBAL-H-promoted bis-de-O-methylation mechanism. Tetrahedron. 2013, 69(20): 4053-4060.

  80. Peng Zhang, Xiaoyan Liu, Yuanjun Zhu, Shizhong Chen, Demin Zhou and Yinye Wang. Honokiol inhibits the inflammatory during cerebral ischemia reperfusion through suppressing NF-kB activation and cytokine production of glial cells. Neuroscience Lett. 2013, 534: 123-127.

  81. Wang H., Xiao SL., Wang Q., Sun DA., Ye M., Zhang LH., Zhou DM*. Elucidation of the pharmacophore of echinocystic acid as a new lead for blocking HCV entry. Eur. J. Med. Chem. 2013, 64: 160-168.

  82. Hongliang Yu, Xiaoying Li, Shaoqian Sun, Xianshu Gao, Demin Zhou*. c-Met inhibitor SU11274 enhances the response of the prostate cancer cell line DU145 to ionizing radiation. Biochem. Biophys. Res. Comm. 2012, 427: 659-665.

  83. Xiao SL, Wang Q, Yu F, Peng YY, Zhou DM*. Conjugation of cyclodextrin with fullerene as a new class of HCV entry inhibitors. Bioorg. Med. Chem. 2012, 20(18): 5616-5622.

  84. Jin X. and Zhou DM*. Strand antagonism in RNAi: An explanation of potency variation of dsRNA versus shRNA generated intracellularly. Nucleic Acd. Res. 2012, 40(4): 1797-1806.

  85. Xiao, S, Zhou DM and Zhang Y. Facile preparation of two tetrols from permethylated α-cyclodextrin and unambiguous NMR analysis. Tetrahedron Lett. 2011, 52(41): 5273-5276.

  86. Zhou DM*, Zhang J, Wang CY and Wong-staal F, A method for detecting and preventing negative RNA interference in preparation of lentiviral vector for siRNA delivery. RNA. 2009, 15: 732-740.

  87. Yu D, Macdonald J, Liu G, Ke N, Zhou DM, Wong-Staal F. Pyrvinium targets the unfolded protein response to hypoglycemia and its anti-tumor activity is enhanced by combination therapy. PLoS ONE, 2008: e3951.

  88. He QC, Tang HL, Zhang J, Wong-Staal F and Zhou DM*. Comparison of RNAi approaches for validation of human RNA helicase A as an essential factor in hepatitis C virus replication. J Viro Methods. 2008, 154: 216-219.

  89. Zhou DM*, Wang CY, Zhang J, Ke N, Bliesath J and Wong-staal F. Generation of shRNA pool library: revise the biological technique from the viewpoint of chemistry. ChemBioChem 2008, 9: 1365-1367.

  90. Zhang J, Wang CY, Ke N, Bliesath J, Chatterton JE, Wong-Staal F and Zhou DM*. A more efficient RNAi inducible system for tight regulation of gene expression in mammalian cells and xenograft animals. RNA. 2007, 13: 1375-1383.

  91. Ke, N., Zhou DM, Chatterton JE, Liu GH, Chionis J, Zhang J, Tsugawa L, Lynn R, Yu DH, Meyhack B, Wong-Staal F, Li QX, A new inducible RNAi xenograft model for assessing the staged tumor response to mTOR silencing. Exp Cell Res. 2006, 312: 2726-2734.

  92. Zhou DM*, He, QC, Zhang J, Wang CY and Wong-staal F, “RNA interference and potential applications”, Cur Topic in Med Chem. 2006, 6, 901-911.

  93. Ke, N., Zhou DM, Fan WF, Chatterton JE, Sundaram R, Chionis J, Zhang J, Hu XY, Yu DH, Awald T, Meyhack B, Brachat A, Paoni NF, Wong-Staal F, Li HQ. Discovery and in vivo validation of novel cancer targets of orphan receptor and protein kinase using inducible RNAi xenograft models. Clinical Cancer Research. (2006) 11(24), 9164.

  94. Zhou DM, Yuen P, Chu D, Thon V, McConnell S, Brown S, Tsang A, Pena M, Russell A, Cheng JF, Nadzan AM, Barbosa MS, Dyck JRB, Lopaschuk GD, Yang G, “Expression, purification and characterization of human malonyl-CoA decarboxylase”, Protein expression & purification, (2004) 34, 261-269.

  95. Zheng LX, Liu J, Zhou DM, Orth A, Ding S and Schultz PG, “An approach to genomewide screens of expressed small interfering RNAs in mammalian cells”, Proc. Natl. Acad. Sci. USA, (2004) 101, 135-140.

  96. A. Wada, T. Shimayama, Zhou DM, M. Warashina, T. Koguma, & Taira, K. "Controlled Drug Delivery: The Next Generation", Park, K. (Ed.), ACS Professional Reference Book, American Chemical Society, Washington, DC, 357-385 (2003).

  97. Zhou DM, et al. “Existence of efficient divalent-metal-ion-catalyzed and inefficient divalent-metal-ion-independent channels in reactions catalyzed by a hammerhead ribozyme”, Nucleic Acid Research, (2002) 30, 3300-5.

  98. Zhou DM,  He Q, Zhou J., Baba T. & Taira K., "Comparison of the kinetic process of RNA cleavages by a DNA enzyme and RNA enzyme”. Biomacromolecules, (2002) 3, 69-83.

  99. Guo Z, Zhou DM and Schultz PG. “Designing small-molecule switches for protein-protein interactions”. Science,(2000) 288, 2042-2045.

  100. De-Min Zhou & Kazunari Taira, "The hydrolysis of RNA: from theoretical calculations to the ribozyme-mediated cleavage of RNA". Chem. Rev., (1998) 98, 991-1026.

  101. De-Min Zhou, Q. He, J. Zhou, K. Taira, Explanation by a putative triester-like mechanism for the thio effects and Mn2+ rescues in reactions catalyzed by a hammerhead ribozyme. FEBS Lett. (1998), 431(2), 154-160.

  102. De-Min Zhou, L. Zhang & K. Taira, "Explanation by the double-metal-ion mechanism of catalysis for the differential metal ion-effects on the cleavage rates of 5'-oxy and 5'-thio substrates by a hammerhead ribozyme". Proc. Natl. Acad. Sci. USA, (1997) 94, 14343-14348.

  103. De-Min Zhou, B. Yue, J. Cui, M. Cai & L. Zhang, "The Total Synthesis of Sinomendine and its analogs,"Heterocycles, (1997) 45, 439-450.

  104. P. Urvil, De-Min Zhou, K. Shimotohno, P. Kumar & S. Nishkawa, "Selection of RNA Aptamers that Bind Specifically to the NS3 Protease of Hepatitis C Virus," Eur. J. Biochem., (1997) 248, 130-138.

  105. M. Warashina, Y. Takagi, S. Sawata, De-Min Zhou & K. Taira, "Entropically driven enhancement of cleavage activity of a DNA-armed hammerhead ribozyme: mechanism of action of hammerhead ribozyme" J. Org. Chem. (1997), 62(26), 9138-9147.

  106. De-Min Zhou, R. Li, B. Yue & M. Cai, Friedel-0Crafts reaction of bromophenols. Huaxue TongBao, (1997) 5, 42-43.

  107. M. Warashina, S. Fujita, R. Utsunomiya, De-Min Zhou & K. Taira, Mechanism of action of a hammerhead ribozyme: a metalloenzyme,” J. Syn. Org. Chem. Japan, (1997) 55, 375-383.

  108. De-Min Zhou, L. Zhang, P. Kumar & K. Taira, "Ribozyme mechanism revisited: Evidence against direct coordination of a Mg2+ ion with the pro-R oxygen of the scissile phosphate in the transition state of a hammerhead ribozyme-catalyzed reaction" J. Am. Chem. Soc. (1996) 118, 8969-8970.

  109. De-Min Zhou, Nassim Usman, Li-He Zhang, Penmetcha K. R. Kumar & Kazunari Taira, "Evidence for the Rate-Limiting Departure of the 5'-Oxygen in Nonenzymatic and Hammerhead Ribozyme-Catalyzed reactions," J. Am. Chem. Soc., (1996) 118, 5862-5866.

  110. De-Min Zhou, L.Zhang, M. Orita, K. Yoshinari & K. Taira, "Magnesium-mediated cleavage of phosphorus-oxygen bond: a ribozyme reaction," Phosphorus, Sulfur, and Silicon, (1996) 108, 273-276

  111. De-Min Zhou, T. Kohda, S. Koseki, K. Kokuma & K. Taira, "Mechanistic studies of hammerhead ribozymes and their applications in vivo," Biotechnologia, (1996) 4, 183-200

  112. P. Kumar, De-Min Zhou, K. Yoshinari & K. Taira, “Mechanistic studies of hammerhead ribozymes,” Nucleic Acids and Molecular Biology, (1996) 10, 217-230.

参编著作

  1. Xiong W, Sun TT, Jin X and LH Zhang, Zhou DM*. “Inducible RNAi and drug target validation”, in “Medicinal Chemistry of Nucleic Acids”, Zhang LH. Ed.; John Willey & Sons Inc., 2012, 456-487.
  2. Wang Q, and Zhou DM*, “Development of New Technologies for Viral Receptor Discovery”, in “Receptors”, He SP. Ed.; Peking Univ Press, 2012, 120-135.
  3. Yang J, Zhou DM and Wong-Staal F, “Screening of Small-Molecule compounds as Inhibitors of HCV Entry” in “Methods in Molecular Medicine, Hepatitis C Protocols”, Tang, H. Ed.; Human Press: 2009, 510: 295-304.
  4. M. Warashina, Zhou DM, T. Kuwabara & K. Taira , "Comprehensive Natural Products Chemistry", Söll, D.; Nishimura, S. Eds.; Elsevier Science, 235-278 (2003).

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