当前位置：首页 > 周德敏课题组 > 课题组成员
课题组成员

肖苏龙 研究员，博士生导师

                                                                                       3-肖苏龙.jpg

                                                                                    E-mail: slxiao@bjmu.edu.cn

                                                                                                         电话：010-82805607

 
  教育经历

1994.09 – 1998.07  北京医科大学，药物化学专业，本科

2000.09 – 2004.07  北京大学，药物化学专业，硕士，导师：杨铭教授

2006.09 – 2011.01  北京大学，药物化学专业，博士，导师：杨铭教授

2007.09 – 2008.09  北京大学-彼埃尔-玛丽居里大学，中法联合培养博士（留学基金委），导师：杨铭教授（中），张勇民院士（法）

工作经历

1998. 08 – 1999.07       北京医科大学，天然药物及仿生药物国家重点实验室，实习研究员

1999. 08 – 2014.07       北京大学医学部，天然药物及仿生药物国家重点实验室，助理研究员

2014. 08 – 2017.12       北京大学医学部，天然药物及仿生药物国家重点实验室，副研究员，硕士研究生导师

2018. 01 – 2021.07       北京大学医学部，药物化学系，副研究员，博士研究生导师

2021. 08 – 至今            北京大学医学部，药物化学系，研究员

研究方向

  • 调控病毒-细胞识别的新型抗病毒天然产物的结构修饰及机制研究；

  • 非天然氨基酸定点修饰蛋白质的生物治疗研究；

  • 环糊精的结构修饰及多价化在药物研发中的应用

科研基金  

  1. 国家自然科学基金面上项目：神经氨酸酶-转铁蛋白受体1结合介导流感病毒内吞的分子机制及干预研究（No.22377006, 2024-2027）

  2. 国家自然科学基金国际合作与交流项目：靶向病毒膜蛋白抗新冠及流感病毒进入的新型二萜及三萜衍生物的合成、活性及机制研究（No. 82161148006, 2021-2023）

  3. 国家自然科学基金面上项目：基于五环三萜-HR2螺旋结构域选择性结合广谱抑制病毒-细胞膜融合的机制研究（No. 21877007, 2019-2022）

  4. 植物化学与西部资源持续利用国家重点实验室（开放课题）：缀合环糊精的三萜新衍生物的合成及其调控流感病毒进入细胞的分子机制研究 （No.P2018-KF06, 2018-2020）

  5. 国家科技重大专项（参与）：基于蛋白质定点修饰关键技术的生物药物创新及升级换代（No. 2017ZX09309009, 2018-2020）

  6. 国家重点研发计划“蛋白质机器与生命过程调控”专项（参与）：“信号转导过程中蛋白质机器的活细胞标记与在体调控”项目之子课题3：“活细胞及活体内蛋白质功能的原位研究与靶向干预”（No.2016YFA0501500, 2017-2021）

  7. 国家自然科学基金重点项目（参与）：海洋微生物来源新型抗流感病毒先导分子的发现与作用机制研究（No. 81630089, 2017-2021）

  8. 国家自然科学基金面上项目：新型五环三萜-环糊精多价物的合成、抗流感进入构效关系及分子机制研究（No. 81573269, 2016-2019）

  9. 国家自然科学基金面上项目：以“病毒进入细胞”为靶的五环三萜抗HCV病毒药物研究（No. 81373271, 2014-2017）

  10. 国家自然科学基金国际合作与交流项目（参与）：基于三萜类化合物调控流感病毒与宿主细胞识别的新型抗病毒药物研究 （No. 81361168002, 2014-2017）

  11. 国家自然科学基金青年基金（参与）：调控流感病毒与宿主细胞识别的传统中药活性成分及其分子机制研究（No. 81202975, 2013-2015）

  12. 科技部“973”重大研究计划（参与）：基于基因密码子扩展的蛋白质标记新方法（No. 2010CB912300, 2010-2014） 

代表性论文

  1. Hua L,# Yi Y,# Tretyakova E,* Smirnova A, Kazakova O, Xiao S.* Synthesis and bioevaluation of water-soluble β-cyclodextrin–diterpene acid conjugates. Nat. Prod. Res., 2024, DOI:10.1080/14786419.2024.2347449

  2. Zhu X,# Liu R,# Yi Y,# Hua L, Tretyakova E,* Zhang Y, Zhou D,  Xiao S.* Click chemistry can access unnatural N-acetylneuraminic acid–anchored β-cyclodextrin conjugates as potential anti-SARS-CoV-2 entry inhibitors. Tetrahedron Lett., 2024, 140, 155047

  3. Kazakova O,* Ma X, Tretyakova E, Smirnova I, Slita A, Sinegubova E, Zarubaev V, Jin H, Zhou D, Xiao S.* Evaluation of A-ring hydroxymethylene-amino- triterpenoids as inhibitors of SARS-CoV-2 spike pseudovirus and influenza H1N1. J. Antibiot., 2024, 77(1), 39-49

  4. Petrova A, Tretyakova E, Khusnutdinova E, Kazakova O,* Slita A, Zarubaev V, Ma X, Jin H, Xu H, Xiao S.* Antiviral opportunities of Mannich bases derived from triterpenic N-propargylated indoles. Chem. Biol. Drug Des., 2024,  103, e14370

  5. Wang A, Ma H, Yi Y, Zhu S, Yu Z, Zhu J, Mei S, Bahetibike S, Lu Y, Huang L, Yang R, Wang R, Xiao S,* Qi, R.* Oleanolic acid derivative alleviates cardiac fibrosis through inhibiting PTP1B activity and regulating AMPK/TGF-β/Smads pathway. Eur. J. Pharmacol., 2023, 960, 176116

  6. Zhu X,# Yi Y,# Fan Z,# Liu R, Chu X, Wang M, Zhang J, Tretyakova E, Zhang Y, Zhang L, Zhou D, Xiao S.* Novel mono- and multivalent N-acetylneuraminic acid glycoclusters as potential broad-spectrum entry inhibitors for influenza and coronavirus infection. Eur. J. Med. Chem., 2023, 260, 115723

  7. Chen B, Chu X, Liu R, Ma X, Wang M, Zhang J, Jiao P, Gao Q, Ma W, Zhang Y, Zhao C,* Zhou D, Xiao S.* Synthesis of novel pentacyclic triterpenoid derivatives that induce apoptosis in cancer cells through a ROS-dependent, mitochondrial-mediated pathway. Mol. Pharm., 2023, 20, 701-710 

  8. Tret'yakova E,#,* Ma X,# Kazakova O, Shtro A, Petukhova G, Smirnova A, Xu H, Xiao S. Abietic, maleopimaric and quinopimaric dipeptide Ugi-4CR derivatives and their potency against influenza A and SARS-CoV-2. Nat. Prod. Res., 2023, 37(12), 1954-1960

    gnpl_a_2112040_uf0001_c.jpg

  9. 周德敏,* 李海伟, 肖苏龙. 中药抗病毒的物质基础, 从五环三萜说开来. 北京大学学报（医学版）, 2022, 54(5), 832-836

  10. Tret'yakova E,#,* Ma X,# Kazakova O, Shtro A, Petukhova G, Klabukov A, Dyatlov D, Smirnova A, Xu H, Xiao S. Synthesis and evaluation of diterpenic Mannich bases as antiviral agents against influenza A and SARS-CoV-2. Phytochem. Lett., 2022, 51, 91-96

  11. Li H, Wang S, Ma W, Cheng B, Yi Y, Ma X, Xiao S,* Zhang L, Zhou D.* Discovery of pentacyclic triterpenoid PROTACs as a class of effective hemagglutinin protein degraders. J. Med. Chem., 2022, 65(10), 7154-7169.

  12. Liang S,# Ma X,# Li M, Yi Y, Gao Q, Zhang Y, Zhang L, Zhou D, Xiao S.* Novel β-cyclodextrin-based heptavalent glycyrrhetinic acid conjugates: Synthesis, characterization and anti-influenza activity. Front. Chem., 2022, 10, 836955

  13. Chen Y,# Wang X,# Ma X, Liang S, Gao Q, Tretyakova EV, Zhang Y, Zhou D, Xiao S.* Facial synthesis and bioevaluation of well-defined OEGylated betulinic acid-cyclodextrin conjugates for inhibition of influenza infection. Molecules, 2022, 27(4), 1163

     

     

  14. Yi Y, Ma X, Liu R, Chu X, Li H, Zhang J, Gao Q, Zhang Y, Zhang L, Zhou D, Xiao S.* An attempt to synthesize the two monomers of CDTOH: unexpected NMR and X-ray diffraction crystal analysis. Tetrahedron Lett., 2022, 91, 153638.

    微信截图_20220117141451.jpg

  15. Li H, Sun J, Xiao S,* Zhang L, Zhou D.* Triterpenoid-mediated inhibition of virus-host interaction: Is now the time for discovering viral entry/release inhibitors from nature? J. Med. Chem., 2020, 63 (24), 15371-15388

    微信截图_20220117141708.jpg

  16. Li M, Yuan L,* Chen Y, Ma W, Ran F, Zhang L, Zhou D, Xiao S.* Rhodamine B-based fluorescent probes for molecular mechanism study of the anti-influenza activity of pentacyclic triterpenes. Eur. J. Med. Chem., 2020, 205, 112664

  17. Xiao S,* Zhou D, Zhang L, Sinaÿ P, Zhang Y.* Preparation of unsymmetrically 2A,3B,6C(F)-trihydroxy-per-O-methylated α-cyclodextrin and NMR analysis. Tetrahedron Lett., 2020, 61(33),152224.

  18. Chen Y#, Wang X#, Zhu Y#, Si L, Zhang B, Zhang Y, Zhang L, Zhou D, Xiao S.* Synthesis of a hexavalent betulinic acid derivative as a hemagglutinin-targeted influenza virus entry inhibitor. Mol. Pharm., 2020, 17(7), 2546-2554

  19. Wang H, Xu R, Liang S, Ran F, Zhang L, Zhang Y, Zhou D, Xiao S.* Selective and facile deacetylation of pentacyclic triterpenoid under methanolic ammonia condition and unambiguous NMR analysis. Chin. Chem. Lett., 2020, 31(2), 333-336

  20. Wang Y,# Li S,# Tian Z, Sun J, Liang S, Zhang B, Bai L, Zhang Y, Zhou X, Xiao S, Zhang Q, Zhang L, Zhang C,* Zhou D.*Generation of a caged lentiviral vector through an unnatural amino acid for photo-switchable transduction. Nucleic Acids Res., 2019, 47(19), e114.

  21. Liang S,# Li M,# Yu X, Jin H, Zhang Y, Zhang L, Zhou D, Xiao S.* Synthesis and structure-activity relationship studies of water-soluble β-cyclodextrin-glycyrrhetinic acid conjugates as potential anti-influenza virus agents. Eur. J. Med. Chem., 2019, 166, 328-338.

  22. Li H,# Li M,# Xu R,# Wang S, Zhang Y, Zhang L, Zhou D,* Xiao S.* Synthesis, structure activity relationship and in vitro anti-influenza virus activity of novel polyphenol-pentacyclic triterpene conjugates. Eur. J. Med. Chem., 2019, 163,  560-568.

  23. Jiao P, Wang S, Liang S, Li M, Gao Q, Ji D, Chen Y, Li H, Ran F, Zhang Y, Zhang L, Zhou D,* Xiao S.* Facile preparation and characterization of novel oleanane-type triterpene functionalized β-cyclodextrin conjugates. Chin. Chem. Lett., 2019, 30(3), 690-693.

  24. Si L, Meng K, Tian Z, Zhang Z, Soloveva V, Li H, Fu G, Xia Q, Xiao S, Zhang L, Cunningham J. M, Zhou D.* Triterpenoids manipulate a broad range of virus-host fusion via wrapping the HR2 domain prevalentin viral envelopes. Sci. Adv., 2018, 11(4), eaau8408.

  25. Li M, Li H, Liang S, Tian Z, Zhou D, Xiao S.* Recent progresses of novel anti-influenza entry inhibitors. Sci. Sin. Chem., 2018, 48(11), 589-599.

  26. Zhu X, Xiao S, Zhou D, Sollogoub M, Zhang Y*. Design, synthesis and biological evaluation of water-soluble per-O-methylated cyclodextrin-C60 conjugates as anti-influenza virus agents. Eur. J. Med. Chem., 2018, 146, 194-205

  27. Xiao S,* Tian Z, Wang Y, Si L, Zhang L, Zhou D.* Recent progress in the antiviral activity and mechanism study of pentacyclic triterpenoids and their derivatives. Med. Res. Rev., 2018, 38(3), 951-976.

  28. Shi Y,# Si L,# Han X,# Fan Z, Wang S, Tian Z, Li M, Sun J, Jin H, Zhang Y, Zhou D, Xiao S.* Synthesis of novel pentacyclic triterpene-Neu5Ac2en derivatives and investigation of their in vitro anti-influenza entry activity. MedChemComm, 2017, 8, 1531-1541

  29. Meng L, Wang Q, Tang T, Xiao S, Zhang L, Zhou D, Yu F.* Design, synthesis and biological evaluation of pentacyclic triterpene dimers as HCV entry inhibitors. Chin. J. Chem., 2017, 35(8), 1322-1328.

  30. Wang W, Zhao Z, Zhang Z, Zhang C, Xiao S, Ye X, Zhang L, Xia Q, Zhou D.* Redirecting killer T cells through incorporation of azido sugars for tethering ligands. Chembiochem, 2017, 18(21), 2082-2086.

  31. Han X,# Si L,# Shi Y, Fan Z, Wang S, Tian Z, Li M, Sun J, Jiao P, Ran F, Zhang Y, Zhou D, Xiao S.* Synthesis and in vitro anti-influenza virus evaluation of novel sialic acid (C-5 and C-9)-pentacyclic triterpene derivatives. Molecules, 2017, 22(7), 1018.

  32. Tian Z,# Si L,# Meng K, Zhou X, Zhang Y, Zhou D, Xiao S.*  Inhibition of influenza virus infection by multivalent pentacyclic triterpene-functionalized per-O-methylated cyclodextrin conjugates. Eur. J. Med. Chem., 2017, 134, 133-139.

  33. Tian Z, Meng K, Shi Y, Zhang N, Liu X, Jin H, Zhang Y, Zhang L, Zhou D, Xiao S.* Facile preparation of a symmetric hexavalent oleanolic acid/per-O-methylated α-cyclodextrin conjugate with two conformations in solution and unambiguous NMR analysis. Tetrahedron, 2017, 73 (17), 2512-2517. （"Front Cover Article"）

  34. Wu S, Yang L, Sun W, Si L, Xiao S, Wang Q, Dechoux L, Thorimbert S, Sollogoub M, Zhou D, Zhang Y. Design, synthesis and biological evaluation of gentiopicroside derivatives as potential antiviral inhibitors. Eur. J. Med. Chem., 2017, 130, 308-319.

  35. Si L,# Xu H,# Zhou X, Zhang Z, Tian Z, Zhang B, Niu Z, Yao T, Wang Y, Li S, Zhang C, Fu G, Xiao S, Xia Q, Zhang L, Zhou D*. Generation of influenza A viruses as live but replication-incompetent virus vaccines. Science, 2016, 354(6316), 1170-1173.

  36. Wu Y, Zhu H, Zhang B, Liu F, Chen J, Wang Y, Wang Y, Zhang Z, Wu L, Si L, Xu H, Yao T, Xiao S, Xia Q, Zhang L, Yang Z, Zhou D.* Synthesis of site-specific radiolabeled antibodies for radioimmunotherapy via genetic code expansion. Bioconjug. Chem., 2016, 27(10), 2460-2468.

  37. Xiao S,* Wang Q, Si L, Zhou X, Zhang Y, Zhang L, Zhou D.* Synthesis and biological evaluation of novel pentacyclic triterpene α-cyclodextrin conjugates as HCV entry inhibitors. Eur. J. Med. Chem., 2016, 124, 1-9.

  38. Han X, Shi Y, Si L, Fan Z, Wang H, Xu R, Jiao P, Meng K, Tian Z, Zhou X, Jin H, Wu X, Chen H, Zhang Y, Zhang L, Xiao S,* Zhou D.* Design, synthesis and biological activity evaluation of novel conjugated sialic acid and pentacyclic triterpene derivatives as anti-influenza entry inhibitors. MedChemComm, 2016, 7, 1932-1945. ("HOT" Article)

  39. Xu H, Wang Y, Lu J, Zhang B, Zhang Z, Si L, Wu L, Yao T, Zhang C, Xiao S, Zhang L, Xia Q,* Zhou D.* Re-exploration of the codon context effect on amber codon-guided incorporation of non-canonical amino acids in E. coli by the blue-white screening assay. Chembiochem, 2016, 17, 1-12. 

  40. Yu F,* Wang Q, Wang H, Si L, Liu J, Han X, Xiao S, Zhang L, Zhou D.* Synthesis and biological evaluation of echinocystic acid derivatives as HCV entry inhibitors. Chin. Chem. Lett., 2016, 27, 711-713.

  41. Han Wang,# Renyang Xu,# Yongying Shi, Longlong Si, Pingxuan Jiao, Zibo Fan, Xu Han, Xingyu Wu, Xiaoshu Zhou, Fei Yu, Yongmin Zhang, Lihe Zhang, Demin Zhou*, Sulong Xiao*. Design, synthesis and biological evaluation of novel L-ascorbic acid-conjugated pentacyclic triterpene derivatives as potential influenza virus entry inhibitors. Eur. J. Med. Chem., 2016, 110, 376-388.

  42. 俞飞,* 郑永祥, 彭逸云, 周德敏, 肖苏龙*. 齐墩果酸A环及C环内酯衍生物的设计合成. 有机化学, 2016, 36, 512-519.

  43. Sulong Xiao,* Longlong Si, Zhenyu Tian, Pingxuan Jiao, Zibo Fan, Kun Meng, Xiaoshu Zhou, Han Wang, Renyang Xu, Xu Han, Ge Fu,Yongmin Zhang, Lihe Zhang, Demin Zhou*. Pentacyclic triterpenes grafted on CD cores to interfere with influenza virus entry: A dramatic multivalent effect. Biomaterials, 2016, 78, 74-85.

  44. 肖苏龙,* 王晗, 王琪, 韩旭, 徐仁洋, 孟坤, 田振宇, 张礼和, 周德敏.* 基于五环三萜先导结构的抗病毒抑制剂研究进展. 中国科学（化学）, 2015, 45(9), 865-883.

  45. Han Wang,# Fei Yu,# Yiyun Peng, Qi Wang, Xu Han, Renyang Xu, Xiaoshu Zhou, Chuanxing Wan, Zibo Fan, Pingxuan Jiao, Yongmin Zhang, Lihe Zhang, Demin Zhou, Sulong Xiao.* Synthesis and biological evaluation of ring A and/or C expansion and opening echinocystic acid derivatives for anti-HCV entry inhibitors. Eur. J. Med. Chem., 2015, 102, 594-599

  46. Zheng Yongxiang, Yu Fei, Wu Yiming, Si Longlong, Xu Huan, Zhang Chuanling, Xia Qing, Xiao Sulong, Wang Qi, He Qiuchen, Chen Peng, Wang Jiangyun, Zhang Lihe, Taira Kazunari, Zhou Demin.* Broaden the versatility of lentiviral vector as a tool in nucleic acid research via genetic code expansion. Nucleic Acids Res., 2015, 43(11), e73

  47. Maorong Yu, Longlong Si, Yufei Wang, Yiming Wu, Fei Yu, Pingxuan Jiao, Yongying Shi, Han Wang, Sulong Xiao, Ge Fu, Ke Tian, Yitao Wang, Zhihong Guo, Xinshan Ye, Lihe Zhang and Demin Zhou.* Discovery of pentacyclic triterpenoids as potential entry inhibitors of influenza viruses. J. Med. Chem., 2014, 57(23), 10058-10071

  48. Sulong Xiao, Qi Wang, Longlong Si, Yongying Shi, Han Wang, Fei Yu, Yongmin Zhang, Yingbo Li, Yongxiang Zheng, Chuanling Zhang, Chunguang Wang, Lihe Zhang, Demin Zhou.* Synthesis and anti-HCV entry activity studies of new β-cyclodextrin-pentacyclic triterpene conjugates. ChemMedChem, 2014, 9(5), 1060-1070.

  49. Fei Yu, Yiyun Peng, Qi Wang, Yongying Shi, Longlong Si, Han Wang, Yongxiang Zheng, Emily Lee, Sulong Xiao,* Maorong Yu, Yingbo Li, Chuanling Zhang, Hengli Tang, Chunguang Wang, Lihe Zhang, and Demin Zhou,* Development of bivalent oleanane-type triterpenes as potent HCV entry inhibitors. Eur. J. Med. Chem., 2014, 77, 258-268.

  50. Sulong Xiao, Ming Yang, Fei Yu, Lihe Zhang, Demin Zhou, Pierre Sinaÿ, Yongmin Zhang. Synthesis of four mono-functionalized α-cyclodextrin derivatives for confirming DIBAL-H-promoted bis-de-O-methylation mechanism. Tetrahedron, 2013, 69(20), 4053-4060.

  51. Wang Han,# Wang Qi#, Xiao Sulong#, Sun Dian, Ye Min, Zhang Lihe, Zhou Demin. Elucidation of the pharmacophore of echinocystic acid as a new lead for blocking HCV entry. Eur. J. Med. Chem., 2013, 64, 160-168.

  52. Fe Yu, Qi Wang, Zhen Zhang, Yiyun Peng, Yongying Shi, Yongxiang Zheng, Sulong Xiao*, Han Wang, Yongyan Qiu, Xiaoxi Huang, Chuanke Zhao, Chuanling Zhang, Dian Sun, Lihe Zhang and Demin Zhou*. Development of oleanane-type triterpene as a new class of HCV entry inhibitors. J. Med. Chem., 2013, 56, 4300-4319.

  53. Su-long Xiao, Qi Wang, Fei Yu, Yi-yun Peng, Ming Yang, Matthieu Sollogoub, Pierre Sinaÿ, Yong-min Zhang, Li-he Zhang, De-min Zhou. Conjugation of cyclodextrin with fullerene as a new class of HCV entry inhibitors. Bioorg. Med. Chem., 2012, 20 (18), 5616-5622

  54. Su Long Xiao, De Min Zhou, Ming Yang, Fei Yu, Li He Zhang, Pierre Sinaÿ, Yong Min Zhang. Synthesis of two mono-deoxy β-cyclodextrin derivatives as useful tools for confirming DIBAL-H promoted bis-de-O-methylation mechanism. Chin. Chem. Lett. 2012, 23(12), 1315-1318.

  55. Sulong Xiao, Demin Zhou, Ming Yang *, Pierre Sinaÿ, Matthieu Sollogoub, Yongmin Zhang *.Facile preparation of two tetrols from permethylated α-cyclodextrin and unambiguous NMR analysis. Tetrahedron Lett., 2011, 52(41), 5273-5276

  56. Sulong Xiao, Ming Yang, Pierre Sinaÿ, Matthieu Sollogoub*, Yongmin Zhang*. Diisobutylaluminum hydride (DIBAL-H) promoted secondary rim regioselective demethylations of permethylated β-cyclodextrin: a mechanistic proposal. Eur. J. Org. Chem., 2010, 2010(8), 1510-1516

  57. Zhang, Z.; Wang, H.; Du, L. Y.; Chen, K. B.; Xiao, S. L.; Yu, F.; Zhang, L. H.; Zhou, D. M. Discovery and development of antiviral drugs. J. Chin. Pharm. Sci., 2010, 19(6), 409-422

  58. Zhi-Dong Xu, Min Wang, Su-Long Xiao, Ming Yang. Novel peptide derivatives of Bleomycin A5: synthesis, antitumor activity and interaction with DNA. Bioorg. Med. Chem. Lett., 2005, 15(18), 3996-3999

  59. 王  敏, 肖苏龙, 徐志栋, 屠鹏飞, 于晓琳, 杨  铭. 具有抗HIV-1 Tat-TAR RNA结合活性的海藻糖新衍生物的设计和合成. 中国新药杂志, 2004, 13(10), 907-911

  60. Wang Min, Xu Zhidong, Tu Pengfei, Yu Xiaolin, Xiao Sulong, Yang Ming. α,α-Trehalose derivatives bearing guanidino groups as inhibitors to HIV-1 Tat–TAR RNA interaction in human cells. Bioorg. Med. Chem. Lett., 2004, 14(10), 2585-2588

  61. Zhi-Dong Xu, Min Wang, Su-Long Xiao, Yan-Juan Zhang, Ming Yang. Novel Bleomycin analogues: synthesis, antitumor activity, and interaction with DNA. Helv. Chim. Acta, 2004, 87(11), 2834-2841

  62. Zhi-Dong Xu, Min Wang, Su-Long Xiao, Chun-Li Liu and Ming Yang.  Synthesis, biological evaluation and DNA binding properties of novel Bleomycin analogues. Bioorg. Med. Chem. Lett., 2003, 13(15), 2595–2599

  63. Zhi-Dong Xu, He Liu, Su-Long Xiao, Ming Yang, Xian-He Bu. Synthesis, crystal structure, antitumor activity and DNA-binding study on the Mn(II) complex of 2H-5-hydroxy-1,2,5-oxadiazo[3,4-f]1,10-phenanthroline. J. Inorg. Biochem., 2002, 90(3-4), 79-84

  64. Xu Zhidong, Liu He, Wang Min, Xiao Sulong, Yang Ming, Bu Xianhe. Cobalt (II) complex of 6,7-dicycanodipyridoquinoxaline with antitumor activities: synthesis, crystal structure and binding with DNA. J. Chin. Pharm. Sci., 2002, 11(4), 125-131

  65. Zhi-Dong Xu, He Liu, Min Wang, Su-Long Xiao, Ming Yang, Xian-He Bu.  Manganese (II) complex of 6,7-dicycanodipyridoquinoxaline with antitumor activities: synthesis, crystal structure and binding with DNA. J. Inorg. Biochem., 2002, 92(3-4), 149–155

  66. 肖苏龙, 杨　铭.人免疫缺陷病毒-1整合酶及其抑制剂的研究进展. 国外医学（药学分册）, 2002, 29(3), 157-161

  67. Su-long Xiao, Wei Lin, Chao Wang, Ming Yang. Synthesis and biological evaluation of DNA targeting flexible side-chain substituted β-carboline derivatives. Bioorg. Med. Chem. Lett., 2001, 11(4), 437-441

  68. 杨铭, 肖苏龙, 周田彦, 张家美, 王保怀, 李芝芬, 孟兴莲, 王夔. 新的手性铂络合物与DNA两种不同结合方式中的分子识别. 北京医科大学学报, 2000, 32(3), 198-202

参编著作 

  1. 药物研究中的分子识别（第2版）（杨铭主编，北京大学医学出版社，2015.8）

  2. 抗肿瘤抗病毒药物与核酸相互作用的分子机制（杨铭主编，P99-138，北京大学医学出版社，2009.4）

  3. 结构生物学概论（杨铭主编，P68-89，北京医科大学出版社, 2002.7.）

 授权或申请专利 

  1. 三萜类化合物及其抗病毒用途。（申请号：2022108018099，肖苏龙、周德敏、马欣源、徐欢）
  2. 一种新的三萜-环糊精共价化合物及其制备方法和用途。周德敏、肖苏龙、司龙龙、俞飞、史勇英、王晗、张礼和（申请号：ZL 2013 1 0684679.6）
  3. 三萜衍生物及其抗流感用途。（申请号：201210402726.9）（发明人：周德敏、于茂荣、肖苏龙、俞飞、彭逸云、邱允俨、张礼和）（2012）
  4. 刺囊酸衍生物及其生物转化方法和用途。（申请号：ZL 2012 1 0015068.8）（发明人：周德敏，王晗， 叶敏，肖苏龙，孙迪安，张礼和）（2012）
  5. 定点突变和定点修饰的病毒膜蛋白、其制备方法及其应用 （ZL 2012 1 0214038.X，周德敏，郑永祥，赵传科，张传领，俞飞，肖苏龙，张礼和）
  6. 定点突变和定点修饰的生长激素、其制备方法及其应用 （ZL 2012 1 0214451.6，周德敏，张传领，肖苏龙，张雨帆，俞飞，赵传科，陈景贤，张礼和）
  7. 具有抗HIV和抗癌活性的3-取代的β-咔啉新化合物，制备方法及其组合物和用途（ZL 011 44531.9，杨铭，林伟，于晓琳，肖苏龙）
  8. 具有抗病毒活性的氨基糖苷类化合物及其制备方法（ZL 02 1 53987.1，杨铭，王敏，徐志栋，肖苏龙）

 

培养研究生

田振宇（2016-2018）    李    曼 （2016-2019）      梁烁斌 （2017-2019）    陈樱璎 （2017- 2020）    高倩倩 （2018-2021） 

谭琳致（2019-2021）    易延亮 （2019-2022）       马欣源 （2020-2023）    楚新当 （2021-2024）   刘芮闻 （2018-2024）

王孟洋 （2022-）          化丽雯（2023-）              张嘉一 （2023-）        段宏高 （2024-    ）                       

 

协助培养研究生

王   晗  （2009-2012，2013-2016）  俞    飞 （2010-2013）   彭逸云 （2011-2013）  史勇英 （2012-2014） 韩    旭 （2014-2016）

徐仁洋 （2014-2016）  司龙龙 （2012-2017）    焦平轩 （2014-2019）  李海伟 （2017-2019，2019-2022）

 

本科生

邱允俨  （2011）        楚新当 （2021）

 

荣誉奖励

  1. 北京大学优秀党务工作者（奉献奖）（2023.06）

  2. 北京大学招生先进个人（2020.12）

  3. 北京大学药学院优秀共产党员 （2018.06）

  4. 北京大学医学部大学生创新实验三等奖（指导教师）（2018.05）

  5. 北京大学医学部SCI论文引用奖（2017.03）

  6. 中国药学大会暨第十五届中国药师周优秀论文二等奖 (2015.11)

  7. 北京大学医学部大学生创新实验一等奖（指导教师）（2014.12）

  8. 第三届中法药学交流会暨产业化推进会优秀墙报奖 三等奖 （2014.08）

  9. 北京大学黄廷芳/信和青年杰出学者奖（2013.12）

  10. 北京大学医学部优秀共产党员（2012.06）

  11. 第十届全国青年药学科技工作者科研成果交流会优秀论文一等奖（2010.07）

  12. Best Poster Award in 2ND ASICEF Workshop on Interdisciplinary Research Topics. (2008.06)

  13. 教育部高等学校科学技术奖(自然科学奖)二等奖(基于病毒基因转录调控机制探索抗HIV新靶标及其新型抑制剂的研究)(第五)(2007.01)

  14. 北京市科技进步二等奖（项目名称：以核酸分子识别为基础新型HIV抑制剂的研究）（第六）（2005.02）

  15. 教育部提名国家科学技术奖（自然科学奖）二等奖（项目名称：抗肿瘤抗病毒药物研究中的分子识别）（第五）（2004.02）

  16. 第六届全国青年药学科技工作者学术交流会优秀论文一等奖（第三）（2002.09）

  17. 北京大学医学部优秀教师（2002.09）

 

课题组活动

 

精彩花絮

J Med Chem2.jpg  

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

点击次数：36796  更新时间：2013-12-29 17:08:56  【打印此页】  【关闭】
上一条：返回列表  下一条：张传领 副研究员，硕士生导师