易延亮 硕士 （2019-2022）

 

E-mail：yiyanliangh@qq.com

毕业去向

江苏先声药业有限公司

 

教育经历 

2015.09-2019.06   南京工业大学 药物制剂 本科 

2019.09-2022.07   北京大学  化学生物学专业，硕士，导师： 肖苏龙 研究员

 

代表性论文

1. Hua L,^# Yi Y,^# Elena V,^* Anna A, Oxana B, Xiao S.^* Synthesis and bioevaluation of water-soluble β-cyclodextrin–diterpene acid conjugates. Nat. Prod. Res., 2024, DOI:10.1080/14786419.2024.2347449
2. Zhu X,# Liu R,# Yi Y,# Hua L, Tretyakova E,* Zhang Y, Zhou D, and Xiao S.* Click chemistry can access unnatural N-acetylneuraminic acid–anchored β-cyclodextrin conjugates as potential anti-SARS-CoV-2 entry inhibitors. Tetrahedron Lett., 2024, 140, 155047
3. Zhu X,# Yi Y,# Fan Z,# Liu R, Chu X, Wang M, Zhang J, Tretyakova E, Zhang Y, Zhang L, Zhou D, Xiao S.* Novel mono- and multivalent N-acetylneuraminic acid glycoclusters as potential broad-spectrum entry inhibitors for influenza and coronavirus infection. Eur. J. Med. Chem., 2023, 260, 115723
4. Yi Y, Ma X, Liu R, Chu X, Li H, Zhang J, Gao Q, Zhang Y, Zhang L, Zhou D, Xiao S*. An attempt to synthesize the two monomers of CDTOH: unexpected NMR and X-ray diffraction crystal analysis. Tetrahedron Lett., 2022, 91, 153638.
5. Li H, Wang S, Ma W, Cheng B, Yi Y, Ma X, Xiao S,* Zhang L and Zhou D.* Discovery of pentacyclic triterpenoid PROTACs as a class of effective HA protein degraders. J. Med. Chem., 2022, 65(10), 7154-7169
6. Liang S,# Ma X,# Li M, Yi Y, Gao Q, Zhang Y, Zhang L, Zhou D, Xiao S.* Novel β-cyclodextrin-based heptavalent glycyrrhetinic acid conjugates: Synthesis, characterization and anti-influenza activity. Front. Chem., 2022, 10, 836955
7. Wang A, Ma H, Yi Y, Zhu S, Yu Z, Zhu J, Mei S, Bahetibike S, Lu Y, Huang L, Yang R, Wang R, Xiao S,* Qi R.* Oleanolic acid derivative alleviates cardiac fibrosis through inhibiting PTP1B activity and regulating AMPK/TGF-β/Smads pathway. Eur. J. Pharmacol., 2023, 960, 176116
8. Yu Y,# Yi Y#, Li Y, et al. Dispersible MoS2 micro-sheets induced a proinflammatory response and apopotosis in the gills and liver of adult zebrafish. RSC Adv., 2018, 8(32), 17826-17836
9. Yu Y, Wu, Na, Yi Y,  et al. Dispersible MoS2 nanosheets activated TGF-beta/smad pathway and perturbed the metabolome of human dermal fibroblasts. ACS Biomaterials Sci Eng., 2017, 3(12), 3261-3272

 

毕业感言
      非常幸运能够进入北医学习，感谢每一位老师、同学的关心和帮助！即将毕业，怀着北医厚道精神继续前行。

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      越努力，越幸运